Photo: Thomas P. Cappola, MD, ScM
Thomas P. Cappola, MD, ScM
Year elected: 2012
Current membership category: Active
University of Pennsylvania
11-113 South Pavillion
3400 Civic Center Blvd.
Philadelphia, PA 19104
United States of America
Phone: 215-662-3140
Facsimile: 215- 349-8017

Biographical statement

My laboratory uses the tools of clinical investigation and applied genomics to reveal mechanisms of human heart failure. This has included establishing a multicenter cohort study of advanced heart failure (Penn Heart Failure Study; PHFS) and a multicenter consortium for human myocardial transcriptomics and eQTL mapping (Myocardial Applied Genomics Network; MAGNet). Notable discoveries include the first demonstration that peripheral blood gene expression provides a clinical biomarker to track cardiac allograft rejection, identification of abnormalities in forkhead signaling and neuregulin signaling in common forms of human heart failure, and discovery of the 1p36 HSPB7/CLCNKA locus as the first bonafide genetic risk factor for non-familial heart failure.

Institutional affiliations

University of Pennsylvania Perelman School of Medicine (Primary)
Ben Z. Stanger, MD, PhD is the representative at this institution.

Specialties

Cardiovascular Medicine
Clinical research
Experimental Therapeutics
Genomics