The Königshoff Lab focuses on deciphering mechanisms involved in lung injury, aging and regeneration, with the aim to identify novel therapeutic targets relevant for chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis. The translational research program focuses on the comprehensive characterization of biospecimen from human tissue and patient cohorts, including broad phenotyping of lung cells using state of the art molecular and computational biology tools. Current studies investigate the role of developmental pathways and stem cells in chronic lung diseases. The laboratory further pioneered the development and applications of clinically relevant patient-derived 3D human tissue based models, such as precision cut lung slices and organoids hat allow to further validate and test potential novel drugs in an individualized fashion.