Photo: Brendan Lee, MD, PhD
Brendan Lee, MD, PhD
Year elected: 2008
Current membership category: Active
Professor & Chairman
Department of Molecular and Human Genetics at Baylor College of Medicine
One Baylor Plaza, Room R814
Houston, TX 77030
United States of America
Phone: 713-798-8835
Facsimile: 713-798-5168

Honors and awards

National Academy of Medicine (2013)
Fellow, American Association for the Advancement of Science (2014)
Association of American Physicians (2010)

Biographical statement

Using human skeletal dysplasias and corresponding mouse models, Dr. Lee has focused on identifying novel genetic mechanisms that regulate skeletogenesis. As a graduate student, he identified the first genetic defects for human chondrodysplasias. As a postdoctoral fellow, he identified the gene for Marfan syndrome. As an independent faculty, he identified the consequences of human mutations in two critical transcription factors Runx2 and Lmx1b important in osteoblast differentiation and limb patterning, respectively. Most recently, he has identified the pathogenetic role of a dysregulated collagen post-translational modification in osteogenesis imperfecta. Finally, his study of human skeletal dysplasias has led him to identify critical components of the transcriptional hierarchy that regulates mesenchymal stem cell differentiation to the osteoblastic versus chondrogenic lineages.

Institutional affiliations

Baylor College of Medicine (Primary)
Wolfgang C. Winkelmayer, MD, MPH, ScD is the representative at this institution.


Developmental Biology
Experimental Therapeutics
Gene Transfer/Gene Therapy
Molecular Biology
Translational Medicine