Dr. Lloyd is a Professor of Neurology and Neuroscience at Johns Hopkins University School of Medicine specializing in Neuromuscular Degenerative Diseases. He has a broad background in neuroscience and cell biology, beginning with graduate training in Dr. Hugo Bellen’s lab at Baylor College of Medicine on mechanisms of vesicle trafficking in the Drosophila nervous system. He completed his neurology residency and neuromuscular fellowship at Johns Hopkins in 2008, where he performed postdoctoral work in Dr. Alex Kolodkin’s lab to generate Drosophila models of motor neuron disease, for which he was awarded the Passano Young Investigator Award and S. Weir Mitchell Award through the American Academy of Neurology. He was awarded the American Neurological Association Wolfe Research Prize in 2012 for his work defining the mechanism of axonal transport disruption in a hereditary motor neuropathy. Dr. Lloyd’s laboratory utilizes Drosophila as the primary model system to investigate the pathogenesis of inherited motor neuron diseases, focusing primarily on mechanisms of intracellular transport within motor neurons, including axonal transport, nucleocytoplasmic transport, and endolysosomal trafficking. His lab discovered that nucleocytoplasmic transport disruption is a fundamental pathophysiological defect in Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), and other neurodegenerative diseases.
Dr. Lloyd currently serves as co-director of the Johns Hopkins Myositis Center where he specializes in translational and clinical research in Inclusion Body Myositis, a degenerative muscle disease with clinicopathologic overlap with ALS. He has seen over 200 IBM patients who are enrolled into a large prospective clinical study on IBM, one of the largest such cohorts in the country. His lab generated a xenograft mouse model of IBM which is being used to accelerate drug development for this devastating muscle disease. He has also served as PI for multiple IBM clinical trials and directs a large clinical research team in myositis.
