William Peranteau is a pediatric and fetal surgeon at the Children’s Hospital of Philadelphia. He leads a translational research team whose overarching goal is to develop innovative prenatal and early postnatal gene therapies, including gene editing, for congenital diseases that cause health problems before or shortly after birth. The foundation of their work is based on the hypotheses that normal developmental properties of the fetus allow for efficient and safe institution of gene therapies and that pathology for many diseases, such as lysosomal storge diseases, begins before birth and is difficult to reverse after birth. As such, his team has led some of the initial studies of in utero CRISPR-mediated gene editing demonstrating the safety and feasibility of this approach to rescue animal models of genetic liver, lung and multiorgan diseases. The impact of the Peranteau lab’s work has been recognized by the NIH Office of the Director (New Innovator Award) and has garnered support for IND-enabling studies as part of the NIH Common Fund Somatic Cell Genome Editing Program. Bill’s clinical practice includes general pediatric surgery with a focus on the surgical care of newborns prenatally diagnosed with birth defects and fetal surgery for a select group of patients. Bill obtained his undergraduate degree from Princeton University and his medical degree from the University of Pennsylvania. He completed his General Surgery training at the Brigham and Women’s Hospital and his Pediatric Surgery training and apprenticeship in Fetal Surgery at the Children’s Hospital of Philadelphia.