Justin Taylor, MD, is a physician-scientist devoted to improving outcomes for patients with hematologic malignancies. He is a tenure-track Associate Professor and member of the Translational and Clinical Oncology program at the University of Miami Sylvester Comprehensive Cancer Center. The Taylor lab studies the role of recurrent mutations in hematologic malignancies and how to target them with novel therapeutics using animal modeling, molecular biology and single-cell genomic techniques. The central focus of the lab is on understanding how alterations in nuclear export function due to mutations or overexpression of XPO1 contribute to oncogenesis. The lab uses molecular biology, genomics, proteomics and mouse modeling to determine the mechanisms and potential targetable weaknesses of these genetic alterations. They also study how patients may become resistant to targeted therapies. Specifically, they discovered and are studying recurrent mutations in BTK kinase domain that drive resistance to noncovalent and covalent BTK inhibitors. Dr. Taylor also holds a faculty position in the Department of Medicine, Division of Hematology where he sees patients with hematologic malignancies. He completed residency in Internal Medicine at the Brigham and Women's Hospital and Hematology/Oncology fellowship at Memorial Sloan Kettering Cancer Center followed by post-doctoral training in the lab of Omar Abdel-Wahab, MD. He has published several original research articles as either first or last author in the past few years in the following journals: Science, New England Journal, Nature Precision Oncology and Nature Genetics. He is the principal investigator on grants sponsored by the National Institute of General Medicine (R35), the National Cancer Institute (R01) and the Edward P. Evans Foundation for MDS. He received the Young Physician-Scientist Award from ASCI in 2021 and the Eugene J. Sayfie, MD mentor award from the University of Miami in 2023. He received the Schally Award for Research achievements from the Miller School of Medicine in 2023.