Nilay S. Sethi, MD, PhD, is an Assistant Professor of Medicine at Harvard Medical School and a medical oncologist at Dana-Farber Cancer Institute. Dr. Sethi was born and raised in New Jersey and received his BS from The College of New Jersey, his MD from Rutgers Robert Wood Johnson Medical School, and his PhD in molecular biology from Princeton University, where his graduate training was in the lab of Yibin Kang. He completed a residency in Internal Medicine at the University of California, San Francisco followed by a Hematology/Medical Oncology fellowship in the Dana-Farber/Mass General Brigham program. His postdoctoral research was at the Dana-Farber Cancer Institute and the Broad Institute in the lab of Dr. Adam Bass. Dr. Sethi started his laboratory at the Dana-Farber Cancer Institute in 2021 where he remains as a medical oncologist and lab-based investigator. He splits his time between taking care of patients with gastrointestinal cancers and investigating a subset of these cancers in the laboratory. His group focuses on gene-environment interactions, aberrant plasticity, and epigenetic regulation of GI premalignancies. In particular, his team is uncovering the molecular regulation of differentiation blocks in colorectal cancer, which contributes to aberrant plasticity in cancer initiation and therapy resistance. By leveraging data from patients, mouse models, and cell culture studies, he is motivated to provide an integrated understanding of early events in gastrointestinal cancers with the ultimate hope that the knowledge gained will inspire new avenues for cancer prevention and treatment. @LabSethi