Matt Greenblatt, MD, PhD, is a physician scientist who leads a research program discovering new stem cells in the skeleton and understanding how these stem cells each play different protective and pathogenic roles in skeletal diseases. After completing an MS/BS program at Yale University, he then performed MD and PhD studies at Harvard University, completing his PhD in the laboratory of Dr. Laurie Glimcher. Receiving a NIH Director’s Early Independence Award and a Burroughs Wellcome Career Award for Medical Scientists allowed him to transition directly to establishing a research lab after completing residency in pathology at Brigham and Women’s Hospital. Currently he is an Associate Professor in the Department of Pathology and Laboratory Medicine at Weill Cornell Medical College. Highlights of his work include identification of SLIT3 as an angiogenic factor driving bone formation and discovery of a stem cell on the outer surface of bones. Whereas other skeletal stem cells form bone by first depositing a cartilage template that is later remodeled into bone or endochondral ossification, this new stem cell is specialized for bone formation without a cartilage template, or intramembranous bone formation. Thus, this work identified a cellular basis for the two basic forms of bone formation, intramembranous versus endochondral ossification. His work also identified that bone contains several distinct stem cells, each with different locations and functions. In addition to his research, he serves as a pathologist at New York Presbyterian Hospital.
Matthew Blake Greenblatt, MD, PhD