Dr. Jennifer Yu is a Staff Physician-Scientist in the Department of Radiation Oncology, Department of Cancer Biology at the Cleveland Clinic, Associate Professor in the Cleveland Clinic Lerner College of Medicine, and co-Leader of the Developmental Therapeutics Program and co-Leader of the Cancer Stem Cell Working Group at the NCI-designated Case Comprehensive Cancer Center.  She specializes in radiation oncology with a focus on brain tumors. She is the Founding Director of the Center for Hyperthermia at the Cleveland Clinic. Her laboratory has made seminal contributions in the understanding of the glioblastoma cellular hierarchy as it relates to different microenvironmental contexts. Glioma stem cells (GSCs) reside in different niches, including the perivascular and hypoxic niches. Her laboratory has found that GSCs in different niches utilize distinct pathways to maintain stemness. Her lab discovered new mechanisms of regulation of two of the most important stem cell regulatory pathways, the Notch and Wnt pathways, in GSCs in these different niches. As a result, tailored approaches are needed to kill GSC populations in the different niches. Active areas of research include understanding mechanisms of cell state regulation and therapeutic resistance, and role of neural activity in cancer progression. She also serves as PI on early phase investigator-initiated clinical trials for glioblastoma. Dr. Yu completed her MD and PhD degrees at Columbia University and radiation oncology residency at the University of California, San Francisco. She served as President of the Society for Thermal Medicine Radiation Oncology Representative of the Society for Neuro-Oncology and serves on the American Brain Tumor Association Clinical Advisory Board.  Dr. Yu was named a Top Oncologist by Ohio Magazine, a recipient of the Gita Gidwani Mid-Career Leadership Fellowship, Lerner Rising Star Award, Cleveland Clinic Excellence in Science Award, and elected to American Society for Clinical Investigation in 2020.