I am the Evnin Family Chair of Molecular Pharmacology at Memorial Sloan Kettering Cancer Center (MSK) where I also serve as Chair of the Molecular Pharmacology Program in the Sloan Kettering Institute and an Attending Physician on the Leukemia Service in the Department of Medicine. I am also a co-Director of the Hematology/Medical Oncology Fellowship program at MSK.

My research focuses on understanding the functional implications of somatic mutations found in patients with hematopoietic malignancies with the hopes of improving our understanding of disease biology and developing novel therapies. Over the last ten years, my laboratory has been focused on understanding alterations in the process of RNA splicing in cancer. Motivated by the discovery of high frequency mutations in the splicing machinery in leukemias and certain solid tumors, my lab’s work has led to the development of several therapeutic approaches for these genetic subtypes of cancer which are currently in phase 1/2 clinical trials. In addition, my laboratory has performed a number of studies of molecular genetics and genomics of blood cancers more broadly and used this information to develop novel therapeutic approaches for myeloid and lymphoid hematologic cancers.

Our research is supported by the National Cancer Institute, National Heart, Lung, and Blood Institutes, the Leukemia & Lymphoma Society, the Department of Defense, the American Society of Hematology, and numerous additional philanthropic organizations. My work has been recognized by a Seldin-Smith Award for Pioneering Research from the American Society for Clinical Investigation, the Dameshek Award from the American Society of Hematology, and the Pershing Square Sohn Prize for Young Investigators in Cancer Research.