Mary Whooley MD FACP FAHA FACC FAMIA is a primary care physician, clinical informatician, health services researcher, Professor of Medicine, Epidemiology & Biostatistics, and Director of the Center for Healthcare Improvement and Medical Effectiveness (CHIME) at the San Francisco VA and University of California, San Francisco. Her current work focuses on leveraging clinical research informatics to accelerate the adoption of evidence-based practices and improve the quality of healthcare delivered in the U.S. Veterans Health Administration's and beyond. Dr. Whooley directs the VA Measurement Science Quality Enhancement Research Initiative and serves as Principal Investigator (PI) of the >25-year Heart and Soul Study, which established that depressive symptoms are stronger predictors of health-related quality of life than objective measures of physical health (JAMA, 2003) and demonstrated that the increased risk of cardiovascular events associated with depressive symptoms can be explained by poor health behaviors such as smoking, medication non-adherence, and physical inactivity (JAMA, 2008). Before embarking on the Heart and Soul Study, she validated a 2-item screening instrument for depression that came to be known as the PHQ-2 (JGIM, 1997). Dr. Whooley received her B.A. from Yale University and M.D. from Boston University School of Medicine before completing her residency and chief residency in Internal Medicine at the University of California, San Francisco (UCSF). She has coauthored over 350 publications and received numerous research mentoring awards.