Dr. Srivastava is Director of the Gladstone Institute of Cardiovascular Disease and the Wilma and Adeline Distinguished Professor of Pediatrics and Biochemistry & Biophysics at the University of California San Francisco (UCSF). Dr. Srivastava completed his residency in the Department of…
more Pediatrics at UCSF, and a fellowship in pediatric cardiology at the Children’s Hospital of Harvard Medical School. His postdoctoral fellowship was at the M.D. Anderson Cancer Center as a fellow of the Pediatric Scientist Development Program before joining the UT Southwestern Medical Center faculty in 1996 where he remained until 2005. Dr. Srivastava’s laboratory investigates the causes of heart disease and uses knowledge of cardiac developmental pathways to devise novel therapeutic approaches for human cardiac disorders. His lab has elucidated cascades of transcriptional and signaling events that control early steps of cardiomyocyte differentiation and morphogenesis. They pioneered the study of microRNAs in the heart and have revealed roles for microRNAs in regulating cardiac cell cycle, morphogenesis and homeostasis. Through the investigation of families with congenital heart disease, they discovered a cause of human cardiac septal defects (GATA4) and valve diseases (NOTCH1) and revealed the mechanisms by which mutations in these genes result in anomalies. Finally, his lab has leveraged developmental studies for regenerative approaches and found that a developmental gene, thymosin 4, has potent properties for cardioprotection and neoangiogenesis in the setting of myocardial infarctions in mice, with clinical trials in humans beginning in 2007. Dr. Srivastava has received numerous honors and awards, including the Richard D. Rowe award and the Mead Johnson award from the Society for Pediatric Research, and has organized several international conferences. He has served on NIH and AHA Study Sections, and is currently serving on a Scientific Advisory Board for the March of Dimes and on the National Heart, Lung and Blood Institute’s Board of External Experts. Dr. Srivastava’s laboratory has trained more than 25 postdoctoral fellows and graduate students and he is committed to the training and development of physician-scientists.
less