ASCI / Young Physician-Scientist Awards, 2024
The Young Physician-Scientist Awards (YPSA) recognize physician-scientists who are early in their first faculty appointment and have made notable achievements in their research.
About the awardee
Jeffrey W. Brown, MD, PhD is physician-scientist at Washington University in St. Louis, School of Medicine where he splits his time between practicing Gastroenterology and studying the molecular processes utilized by normal cells to transform into metaplasia and cancer. Jeff completed his undergraduate studies at Colgate University majoring in chemistry and subsequently joined Boston University’s combined MD-PhD Program. His graduate studies were conducted in the laboratory of C. James McKnight, where he utilized NMR, X-Ray crystallography and electron microscopy to study the structure and dynamics of several cytoskeletal proteins. After graduation, he completed a residency in internal medicine at University of Pittsburgh Medical Center followed by gastroenterology fellowship at Washington University. With interest in studying dynamic processes at a cellular and organ level, he completed a post doc with Jason C. Mills, where he discovered an undescribed cellular process that he calls cathartocytosis and which is used by normal cells to downscale their cellular architecture en route to metaplasia. Determining the protein components and glycosylation epitopes involved in this process is one of the primary research goals of his laboratory.