ASCI / Young Physician-Scientist Awards, 2022
The Young Physician-Scientist Awards (YPSA) recognize physician-scientists who are early in their first faculty appointment and have made notable achievements in their research.
About the awardee
LIndsey A. George, MD, studies the molecular basis of coagulation that in diminished or excess functional states leads to disorders of hemostasis and thrombosis, respectively. Her lab is particularly interested in the intrinsic tenase enzyme complex that, in deficiency states, results in hemophilia A or B. The current primary focus of their work is the regulation of factor VIII cofactor function with the goal of exploiting biochemical understanding to develop gene based therapies for hemophilia A. Dr. George's lab is additionally interested in understanding the mechanistic basis of translational questions that have emerged from hemophilia gene therapy clinical trials. She was previously the lead clinical principal investigator of early phase hemophilia A and B adeno-associated virus-mediated gene addition trials. Lastly, Dr. George is the director of the Clinical In Vivo Gene Therapy at the Children's Hospital of Philadelphia that long-term aims to safely and efficiently advance translational and clinical research for in vivo gene therapy for children with genetic disorders.