Dr. Ganesh is an Associate Professor (with tenure) at the University of Michigan, primarily appointed in the Department of Internal Medicine in the Division of Cardiovascular Medicine, and secondarily appointed in the Department of Human Genetics, at the Medical School. She studies the genetic and molecular basis of vascular traits and diseases. She completed undergraduate and medical school at Northwestern University, after which she trained in Internal Medicine at the University of Michigan, and Cardiology fellowship at Johns Hopkins School of Medicine. She completed her postdoctoral fellowships the National Heart Lung and Blood Institute, National Human Genome Research Institute, and Johns Hopkins School of Medicine, Institute of Genetic Medicine.

Her laboratory employs genetic and genomic analysis methods to identify and study genetic mechanisms of arterial diseases in both adult and pediatric populations, including diseases with notable sex differences in disease manifestation such as arterial fibrodysplasia phenotypes, arterial aneurysm and dissection, and hypertension. Functional analysis of specific genetic findings are pursued in the laboratory using patient-derived cell line models and murine models of disease. Her laboratory has had continuous extramural funding, and she has over 90 peer-reviewed manuscripts. She has mentored both basic research and clinically oriented trainees in her laboratory, and is Associate Editor for JCI Insight.