Photo: Mathias Lichterfeld, MD, PhD
Mathias Lichterfeld, MD, PhD
Year elected: 2015
Current membership category: Active
Harvard Medical School
Brigham and Women's Hospital
65 Landsdowne Street
Cambridge, MA 02139
United States of America
Phone: 617-726-7416
Facsimile: 617-726-5411

Biographical statement

Dr. Lichterfeld’s research interests focus on the pathogenesis of HIV-1 infection, on investigating HIV-1 immune defense mechanisms, and on developing clinical strategies that can reduce residual HIV-1 disease in patients treated with antiretroviral therapy. HIV-1 pathogenesis studies are designed to address fundamental question related to the mechanisms by which HIV-1 causes disease in humans, and through which HIV-1 can establish an extremely long-lasting reservoir of HIV-1 infected cells that persists despite currently available antiretroviral treatment. His work on immune defense mechanisms against HIV-1 includes studies focusing on adaptive CD4 T and CD8 T cell immune responses, and on dendritic cells, immune induction and innate effector cells; many of these investigations are performed in the context of HIV-1 elite controllers, a rare group of HIV-1 infected patients who are able to maintain undetectable levels of HIV-1 replication in the absence of antiretroviral therapy. His clinical research interests include pilot clinical studies that aim at reducing persisting reservoirs of HIV-1 infected cells, and on increasing immune activity against HIV-1; the ultimate aim of these studies is to induce a long-term drug-free remission of HIV-1 infection in larger patient populations. As a practicing infectious disease physician, Dr. Lichterfeld focuses on research projects that take advantage of bi-directional interchanges between mechanistic basic science investigations and translational activities and emphasize direct patient involvement in research studies.

Institutional affiliations

Harvard Medical School, Massachusetts General Hospital (Primary)
Dennis A. Ausiello, MD is the representative at this institution.