Michelle P. Winn, MD
Photo: Michelle Winn

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Elected 2011
The focus of my laboratory is to understand the genetic basis of hereditary focal and segmental glomerulosclerosis (FSGS). We recently discovered the transient receptor potential cation channel, type 6 (TRPC6) as a cause for hereditary FSGS in a large kindred from New Zealand. To date, at least eight other mutations have been found in other families. In addition to searching for genes in other families with FSGS, we also have a large TRPC6 mouse model program to understand the functional significance of the P112Q mutation. Other interests include the genetics of complex diseases as they relate to the kidney such as hypertension, diabetic nephropathy and end-stage renal disease.