Photo: Bjorn C. Knollmann, MD, PhD
Bjorn C. Knollmann, MD, PhD
Year elected: 2010
Current membership category: Senior
Vanderbilt University School of Medicine
2215 Garland Ave, MRB4 Rm 1265
Nashville, TN 37232-0575
United States of America
Phone: 615-343-6493

Biographical statement

My research interest is to determine mechanisms responsible for ventricular arrhythmias and sudden cardiac death. We study genetic mouse models of human arrhythmia syndromes to identify arrhythmia mechanisms. Current focus is on human gene mutations that alter (1) sarcoplasmic reticulum calcium handling and (2) contractile proteins. My basic and translational research program has identified alterations in the function of myofilaments and calcium release channels as new molecular arrhythmia mechanisms in heart muscle diseases. Based on these discoveries, I have tested new antiarrhythmic therapies in animal models and in patients. My goal is to identify new pathways for drug treatment of ventricular arrhythmias, a leading cause of death in the industrialized world.

Institutional affiliations

Christopher S. Williams, MD, PhD is the representative at this institution.

Specialties

Biophysics
Cardiovascular Disease
Cardiovascular Medicine
Drug Development
Experimental Therapeutics
Internal Medicine
Pharmacology