Summary of research - Dr. Levy's specific areas of research interests are endogenous mechanisms for the resolution of acute lung inflammation and injury. His laboratory uses lipidomics to identify natural small molecule regulators of the severity and duration of innate and adaptive immune responses in the lung. During Dr. Levy's post-doctoral training in biochemistry with Charles Serhan and with his current research team, he has laid the groundwork for polyisoprenyl phosphate remodeling to serve as a new counter-regulatory signal transduction pathway in leukocytes and lung parenchymal cells. In addition, his research is focused on the molecular signaling circuits for autacoids that promote resolution, such as lipoxins, protectins and resolvins from rachidonic, docosahexaenoic and eicosapentaenoic acids, respectively. Moreover, he is linking these basic observations to the genesis of human illness to gain a molecular understanding of the pathobiology of inflammatory lung disease and to use these insights towards new therapeutic strategies for refractory lung diseases, such as acute lung injury/ARDS and severe asthma.