Christian Vaisse, MD, PhD
Year elected: 2006
Current membership category: Senior
ProfessorUniversity of California San Francisco
Professor in Medicine
513, Parnassus Avenue, Room HSW1113
San Francisco, CA 94143-0540
United States of America
Phone: (415) 514 0530
Facsimile: (415) 564 5813
The overall goal of our research is to identify genetic defects implicated in the onset and progression of multi-factorial metabolic diseases such as obesity and type 2 diabetes. We are in particular concentrating our research on the molecular mechanisms implicated in the hypothalamic effects of the adipocyte secreted, weight-regulating hormone, leptin. We have, for example, demonstrated that mutations in the Melanocortin-4 receptor, a downstream effector of leptin signaling in the brain, are the cause of up to 5% of severe obesity cases in humans. Both through in vitro and in vivo studies we are determining how these mutations cause obesity and what the implications are for the treatment of this condition. More broadly, our laboratory combines human genetic approaches with molecular biology and animal studies to find new genes in which mutations predispose to obesity or type 2 diabetes in humans and to determine the impact and functional effects of these mutations.
University of California, San Francisco, School of Medicine (Primary)
Suneil K. Koliwad, MD, PhD is the representative at this institution.