Susan E. Quaggin, MD
Year elected: 2006
Current membership category: Senior
Professor/Director FCVRI/Chief NephrologyNorthwestern Feinberg School of Medicine
Simpson-Querrey Biomedical Research Building
303 E. Superior Street
Chicago, IL 60611
United States of America
Honors and awards
National Academy of Medicine (2019)
To understand the pathways and interactions between different cell types in the glomerulus that are critical to set up the filtration barrier Dr. Quaggin’s research team has developed a number of genetic tools that permit cell and time-specific manipulation of gene expression. Using these tools, her lab has shown that VEGF-A is a major angiogenic factor required in the glomerulus. 'Tweaking' the dose of VEGF-A within the glomerulus leads to distinct and dramatic glomerular phenotypes during development and in adult mice. These phenotypes resemble a variety of glomerular lesions from preeclampsia, to focal segmental glomerulosclerosis, two major causes of renal disease in patients. Loss of all VEGF-A within the glomerulus results in a complete failure of the filtration barrier to form. Dr. Quaggin's lab is currently dissecting the upstream and downstream effectors of the VEGF-A signaling pathway that include the transcription factor, Pod1, and the Von Hippel Lindau tumour suppressor gene.
Northwestern University Feinberg School of Medicine (Primary)
John Erik Pandolfino, MD, MSCI is the representative at this institution.