Photo: Mukesh K. Jain, MD, FAHA
Mukesh K. Jain, MD, FAHA
Year elected: 2005
Current membership category: Senior
Chief Academic Officer University Hospitals Case Medical Center; Chief Scientific Officer, Harrington Discovery Institute
Case Western Reserve Univ School of Medicine
The Iris S & Bert L Wolstein Res Bldg, Rm 4537
10900 Euclid Avenue, Location Code 4958
Cleveland, OH 44106
United States of America
Phone: 216.368.3607
Facsimile: 216.368.0556

Honors and awards

National Academy of Medicine (2016)

Society service

President, 2014–2015

Biographical statement

Dr. Jain is the Ellery Sedgwick Jr. Chair & Distinguished Scientist; Director, Case Cardiovascular Research Institute and Professor of Medicine, Case Western Reserve University School of Medicine; Scientific Director, Harrington Discovery Institute and Chief Research Officer, Harrington Heart & Vascular Institute at University Hospitals Case Medical Center. Dr. Jain is recognized for discovery of essential roles for the transcription factor family Krüppel-like factors (KLFs) in inflammation and metabolism. In addition, he has translated this corpus of work into animals and humans, thus implicating KLFs in the physiology of inflammatory and metabolic diseases including sepsis, myopathy, diabetes, and vascular dysfunction. As a direct result of this work, KLFs are now increasingly viewed, together with classic regulators such as NFkB and nuclear receptors, as nodal determinants of cellular inflammation and metabolism. Dr. Jain’s clinical and academic contributions are recognized by numerous awards and honors including election to the American Society for Clinical Investigation (ASCI), Association of American Physicians (AAP), and Association of University Cardiologists (AUC). Dr. Jain is a member of the American Heart Association’s Advancement of Science and Basic Science Council, serves on multiple editorial boards, and has been the recipient of numerous NIH grants. Dr. Jain received his MD from the University of Buffalo School of Medicine. He completed his residency in internal medicine at the Beth Israel Hospital in Boston and completed a cardiovascular medicine fellowship at Brigham & Women’s Hospital, Harvard Medical School.

Institutional affiliations

Case Western Reserve University School of Medicine (Primary)
Fabio Cominelli, MD, PhD is the representative at this institution.
University Hospitals Case Medical Center (Secondary)


Cardiovascular Disease
Internal Medicine

Positions held

Institute Director
Laboratory Director