Photo: Bruce Beutler, MD
Bruce Beutler, MD
Year elected: 1990
Current membership category: Senior
Regental Professor and Director
The University of Texas Southwestern Medical Center
Center for Genetics of Host Defense
5323 Harry Hines Boulevard
Suite NB9.202
Dallas, TX 75390-8505
United States of America
Phone: 214-648-5838

Honors and awards

National Academy of Medicine (2008)
National Academy of Sciences (2008)
Nobel Prize in Physiology or Medicine (2011) for discoveries concerning the activation of innate immunity (shared).
ASCI | Stanley J. Korsmeyer Award (2013) in recognition of his contributions to the field of innate immunity.
American Academy of Arts & Sciences (2013)

Biographical statement

Bruce Beutler, MD, is a Regental Professor at the UT Southwestern Medical Center, where he directs the Center for the Genetics of Host Defense.

Dr. Beutler studied medicine at the University of Chicago. Early in his career he isolated mouse TNF and discovered its inflammatory properties, later developing TNF inhibitor proteins that found widespread use in clinical medicine. He then identified Toll-like receptor 4 as the mammalian sensor of bacterial lipopolysaccharides. These groundbreaking studies earned Dr. Beutler the 2011 Nobel Prize in Physiology or Medicine (with J. Hoffmann and R. Steinman).

In the past decade, using statistical computation and artificial intelligence to discover point mutations that cause any measurable phenotype in real time, Dr. Beutler and his team have identified thousands of mutations in hundreds of genes that disrupt normal immune function, development, metabolism, neurobehavioral function, and other biological processes of interest.

Dr. Beutler is a member of the National Academy of Medicine (2008), the National Academy of Sciences (2008), and the American Academy of Arts & Sciences (2013). He is recipient of the Balzan Prize (2007), Albany Medical Center Prize in Medicine and Biomedical Research (2009), the Shaw Prize (2011), and the ASCI Stanley J. Korsmeyer Award (2013).

Institutional affiliations

Helen H. Hobbs, MD is the representative at this institution.



Positions held

Howard Hughes Medical Institute Investigator