Simeon Taylor, MD, PhD
Year elected: 1985
Current membership category: Senior
Professor
University of Maryland School of Medicine
Division of Endocrinology, Diabetes, and Nutrition
HSF-III, Room 4182
670 W. Baltimore Street
Baltimore, MD 21201
United States of America
Phone: 410-706-6439

Biographical statement

During my career as a physician-scientist, I have contributed to several aspects of translational research related primarily to diabetes and endocrinology. While working in the NIDDK Intramural Research Program (1979-2000), my research group conducted research to elucidate mechanisms of insulin resistance. We were best known for identification of mutations in the insulin receptor gene in patients with genetic syndromes of insulin resistance, but also contributed to the literature on mutations causing lipoatrophy/lipodystrophy. In addition, we initiated research related to therapies for lipodystrophy -- including metreleptin and thiazolidinediones. In the next chapter of my career (2000-2013), I served as Vice President of Cardiovascular and Metabolic Disease Research at Bristol-Myers Squibb -- during which time I made substantial contributions to R&D leading to four approved drugs: saxagliptin, dapagliflozin, apixaban, and metreleptin. Since returning to academia (2013-present), my research team has focused on several projects: (1) safety issues related to SGLT2 inhibitors, especially mechanistic studies of the pathphysiology of adverse effects on bone health; (2) pharmacogenomics of SGLT2 inhibitors and GLP1 receptor agonists; and (3) mechanistic studies to elucidate the role of DYRK1B in cardiometabolic physiology. Over the course of my career, I have served in several leadership roles, including: Chief of the Diabetes Branch (NIDDK, NIH); Director of NIH Inter-Institute Training Program in Endocrinology; Vice President of Cardiovascular and Metabolic Disease Research (Bristol-Myers Squibb); Director of NIDDK-funded Mid-Atlantic Nutrition Obesity Research Center (Univ. of Maryland School of Medicine); Director of NIDDK-funded T32 Institutional Training Program in Diabetes.

Institutional affiliations

Charles C. Hong, MD, PhD is the representative at this institution.

Specialties

Biochemistry
Cell Biology
Endocrinology
Genetics
Internal Medicine
Molecular Biology

Positions held

Branch Chief
Professor
Program Director
Vice President